Clinical trials

The following list shows the clinical trials currently open at the two sarcoma centres in London and the South East: University College London (UCH) and The Royal Marsden (RMH). For further information please contact the research nurses at each site:

Last updated 20 April 2016

Name Description Type Centre Suitable for TYA?
ANNOUNCE A randomised, double-blind, placebo-controlled, phase 3 trial of olaratumab plus doxorubicin vs. placebo plus doxorubicin in patients with advanced or metastatic STS Phase III UCH RMH 18+
BLU-GIST A Phase 1 Study of BLU-285 in patients with Gastrointestinal Stromal Tumors (GIST) and other Relapsed and Refractory Solid Tumors. Phase I RMH No
Bone Sarcoma CTC study Optimisation of circulating tumour cell detection in bone sarcomas Translational UCH 4+
CASPS A randomised phase II, multi-centre, double-blind, placebo-controlled trial of cediranib in the treatment of patients with alveolar soft part sarcoma. Phase II UCH
RMH
16+
CREATE Cross-tumoral phase 2 clinical trial exploring crizotinib (PF-02341066) in patients with advanced tumors induced by causal alterations of ALK and/or MET. Phase II UCH Yes
DOREMY study Dose Reduction of preoperative radiotherapy in Myxoid liposarcomas. Radiotherapy, pilot- feasibility study RMH No
Enliven A double-blind, randomised, placebo-controlled phase 3 study of orally-administered PLX3397 in subjects with pigmented villonodular synovitis or giant cell tumor of the tendon sheath Phase III UCH RMH 18+
EQMR Evaluating the feasibility of using whole body T1 mapping MRI in the assessment of differing tumour types and assessing response and changes in tumours to systemic oncological therapy. Imaging UCH Yes
Euro-Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours. Phase III UCLH
RMH
Yes
GOG-0277 A phase III randomized trial of Gemcitabine (NSC# 613327) plus Docetaxel (NSC# 628503) followed by Doxorubicin (NSC# 123127) Versus Observation for uterus-limited high grade uterine leiomyosarcoma. Phase II UCH RMH 18+
IMRIS A phase II study of intensity modulated radiotherapy (IMRT) in primary bone and soft tissue sarcoma. Phase II UCH 16+
KINDRED The International Sarcoma Kindred Study: a global multiā€site prospective cancer genetics study. Translational UCH RMH 16+
MEMOS A mechanistic study Of mifamurtide (MTP-PE) in patients with metastatic and/or recurrent osteosarcoma Phase II UCH 16+
PARAGON A phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasma. Phase II UCH RMH 18+
rEECUr International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory ewing sarcoma. Phase II/III UCH
RMH
Yes
RMS 2005 A study investigating the use of chemotherapy in the treatment of children and teenagers with rhabdomyosaroma. Phase III UCH Yes
STRASS A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with Retroperitoneal sarcoma (RPS). Phase III RMH
UCH
18+